WebJun 4, 2024 · The KOH-promoted chemodivergent benzannulation of ortho-fluorobenzamides with 2-propyn-1-ol can afford either 1,4-benzoxazepin-5(4H)-ones or 1,3-benzoxazin-4(4H)-ones in good yields with high selectivity, … WebMay 25, 2024 · The direct transformation of readily available phenol derivatives into valuable trifluoromethylarenes was developed. The PMe 3 -catalyzed oxidative addition and …
A radical approach to the copper oxidative addition problem
WebNov 27, 2024 · The conversion of easily available trifluoromethylarenes into aryldifluoromethyl compounds, which are valuable motifs in the pharmaceutical chemistry, is highly atom- and step-economical. However, the single C(sp3)–F bond cleavage of ArCF3 is a great challenge because of the chemical inertness of the C(sp3)–F bond and the … Web当前位置: »论坛 › 学术社区 › 学术文献互助交流/求助 › Defluoroalkylation of Trifluoromethylarenes with Hyd ... [ACS] Defluoroalkylation of Trifluoromethylarenes with … pentoxifylline and vitamin e
Mild and efficient conversion of trifluoromethylarenes into ...
WebSelective Late-Stage Hydrodefluorination of Trifluoromethylarenes: A Facile Access to Difluoromethylarenes. Socrates B. Munoz, Socrates B. Munoz. Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, University Park, 90089-1661 Los Angeles, CA, USA. WebMay 20, 2024 · Molecular editing such as insertion, deletion, and single atom exchange in highly functionalized compounds is an aspirational goal for all chemists. Here, we disclose a photoredox protocol for the replacement of a single fluorine atom with hydrogen in electron-deficient trifluoromethylarenes including complex drug molecules. WebThe conversion of easily available trifluoromethylarenes into aryldifluoromethyl compounds, which are valuable motifs in the pharmaceutical chemistry, is highly atom- and step-economical. However, the single C(sp³)–F bond cleavage of ArCF₃ is a great challenge because of the chemical inertness of the C(sp³)–F bond and the difficult selectivity … pentoxifylline and wound healing