Tim4 gene name
Web12 lug 2024 · Cavity-resident macrophages express high levels of Tim-4, a receptor for phosphatidylserine (PS), and this is associated with reduced numbers of CD8+T cells with tumor-reactive features in pleural effusions and peritoneal ascites from patients with cancer.
Tim4 gene name
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WebBackground: Dendritic cell (DC)-derived immunoglobulin domain molecule (TIM)4 plays a critical role in the initiation of T helper (Th)2 polarization. Vitamin D (VitD) involves the regulation of a number of immune responses. Objectives: This study tests a hypothesis that VitD regulates TIM4 expression in DCs. Methods: Peripheral blood samples were … Web26 set 2024 · Gene silencing. The TIM4 gene in splenic DCs and the TIM1 gene in CD4 T cells were knocked down by RNA interfer-ence with reagent kits [Lipofectamine™ 3000 Transfection Reagent (L3000015); Invitrogen, Shanghai, China] following the manufacturer's instructions. The effect of gene silenc ing was assessed by western blotting. Flow …
Web25 set 2024 · Previous studies demonstrated that TIM1 was a susceptibility gene for asthma and allergy, which was preferentially expressed on activated Th2 cells; by contract, TIM4 is mainly expressed on antigen-presenting cells (APCs) ( 8 ). WebStrain Name: C57BL/6-Timd4 tm2(TIMD4) /Bcgen: Common Name : B-hTIM4 mice: Background: C57BL/6: Catalog number: 110837: Aliases : SMUCKLER, TIM4: NCBI Gene ID: 276891: Model validation. mRNA expression analysis. Strain specific analysis of TIM4 gene expression in wild-type C57BL/6 mice and B-hTIM4 mice by RT-PCR. Mouse TIM4 …
Web9 feb 2024 · By a targeted screening of phagocyte receptors, we here identified T cell immunoglobulin mucin receptor 4 (Tim4) ( Miyanishi et al., 2007 ) as a pattern-recognition receptor for carbon crystals. We further characterized Tim4 and another Tim family member, Tim1, as receptors for MWCNTs by biological and computational analyses. Results WebTIM-4 (T cell; immunoglobulin; mucin-4), also known as SMUCKLER, is a 60 kDa member of the TIM family of immune regulating proteins. TIMs are type I transmembrane proteins …
WebNX_Q96H15 - TIMD4 - T-cell immunoglobulin and mucin domain-containing protein 4 - Computed references. Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Involved in regulating T-cell proliferation and lymphotoxin signaling. Ligand for HAVCR1/TIMD1 (By similarity).
WebTIM-4 is also known as Spleen, mucin-containing, knockout of lymphotoxin protein (SMUCKLER). TIM-4 is a single-pass type I membrane transmembrane glycoprotein … scwcc fee scheduleWebTargeted disruption of the Tim4 gene The Tim4-targeted mice were generated as custom order by Unitech (Kashiwa, Chiba, Japan). In brief, the Tim4 chromosomal gene was isolated from BAC clones of C57BL/6 mice, and its exon 1 and most of exon 2 were replaced by a coding sequence for Venus and neo gene (Fig. 1). pdms sheetWebThis Anti-TIM4/TIMD-4 Antibody, clone Kat5-18 is validated for use in Flow Cytometry and Neutralizing for the detection of ... TIMD-4, Smuckler) is encoded by the Timd4 (also known as B430010N18Rik, Tim4) gene (Gene ID 276891) in murine species. Phagocytes, including macrophages, target apoptotic cells for engulfment by recognizing their ... pdms shore hardnessWebwwweee SCIENTIFIC REPORTS 621336 DI 10.103srep21336 2 the expression of TIM4 in DCs, in which both p300 and STAT6 were associated with the regulation of TIM4 gene transcription. Results pdms sheet bondingWeb1 set 2024 · T-cell immunoglobulin and mucin domain ( TIM) gene family includes three members coding for TIM-1, TIM3, and TIM-4 proteins. The genes of this family are located on chromosome 5q33.2 ( Liu et al., 2024 ). pdms solubilityWebTIM-4 (TIMD4) Antibodies TIM-4 (TIMD4) Antibodies Antibodies that detect TIM-4 (TIMD4) can be used in several scientific applications, including Immunohistochemistry, Western … pdms showWebBelongs to the immunoglobulin superfamily. TIM family. Tim4/TIMD4 protein name Recommended name T-cell immunoglobulin and mucin domain-containing protein 4 … pdms shortcut