Platinum ototoxicity
Webbexacerbate ototoxicity, cochlear structures that are most vulnerable to platinum damage, therapies for reducing ototoxicity, and the molecular signaling pathways that lead to cell … WebbBackground: Platinum compounds are a group of fundamental chemotherapeutics used in the treatment of solid tumors, but they are burdened by side effects, such as ototoxicity. …
Platinum ototoxicity
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WebbDrugs may cause hearing loss, dysequilibrium, and/or tinnitus. Common drugs include aminoglycosides, platinum-containing chemotherapy drugs, and high-dose salicylates. … Webb11 nov. 2024 · Platinum-induced ototoxicity has been described as a bilateral, progressive, and irreversible sensorineural hearing loss (HL). It has also been observed that patients …
Webb16 nov. 2024 · Unfortunately, platinum-based therapies cause ototoxicity in many patients, and are particularly harmful to the survivors of pediatric cancer. Each year in the U.S. and Europe there is estimated that over 10,000 children with solid tumors are treated with platinum agents. Webb11 apr. 2024 · In addition, they also had a marked reduction of systemic toxicity since serum platinum, pulmonary toxicity, hepatotoxicity, and nephrotoxicity were not detected, proving their safety. Lan et al. also developed a co-loaded CISPt and anti-PD-1 (a blocker of programmed cell death protein (PD-1) NPs.
WebbNational Center for Biotechnology Information Webb31 mars 2024 · Background: Platinum compounds are a group of fundamental chemotherapeutics used in the treatment of solid tumors, but they are burdened by side effects, such as ototoxicity. The objective of this study was to evaluate the incidence of ototoxicity caused by platinum compounds and [...] Read more.
WebbThe first major recognition of drug-induced hearing loss can be traced back more than seven decades to the development of streptomycin as an antimicrobial agent. Since then at least 130 therapeutic drugs have been recognized as having ototoxic side-effects. Two important classes of ototoxic drugs are the aminoglycoside antibiotics and the platinum …
WebbFennec Pharmaceuticals Inc is a clinical-stage biotechnology company. It is primarily engaged in research and development activities. The company is developing Sodium Thiosulfate (STS), a chemo ... change wifi frequency androidWebbA clinical and pathologic study of cis-platinum ototoxicity was performed. Twenty-four patients treated with cis-platinum for head and neck cancer were studied prospectively. … harford county animal controlWebb17 maj 2024 · The main platinum compounds are cisplatin, carboplatin, and oxaliplatin. Their use in clinical practice has greatly improved long-term survival of pediatric … change wifi frequency on pcWebbOtotoxicity (Concept Id: C0235280) Damage to the inner ear as a result of exposure to drugs or chemicals. Ototoxicity MedGen UID: 66719 •Concept ID: C0235280 Pathologic … harford county apartment rentalsWebb1 mars 2024 · An extensive review of the literature revealed that a variety of criteria are used worldwide for grading platinum-induced hearing loss in children and adults, … harford county annual user benefit assessmentWebbOnce severe ototoxicity has arisen, it is important to help with understanding of the spoken word, as this will greatly support a child’s development. The indication for hearing aids … change wifi frequency 2.4 gWebbPlatinum chemotherapy drugs, such as cisplatin and carboplatin, are the cornerstone of many effective therapeutic protocols for childhood cancer. However, the antitumor … change wifi from 5.0 to 2.4