WebStructural and Functional Characterization of CRM1-Nup214 Interactions Reveals Multiple FG-binding Sites Involved in Nucleocytoplasmic Transport . Bibliographic Details; Main Author: ... Chromatin-bound CRM1 recruits SET-Nup214 and NPM1c onto HOX clusters causing aberrant HOX expression in leukemia cells by: Masahiro Oka, et al. Published: ... WebAbstract 473 highlights the dose dependent reduction of menin target genes in ex vivo chronic lymphocytic leukemia (CLL) patient samples treated with BMF-219, an investigational covalent...
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Web7 feb. 2024 · NPM1 ablation induces HSC aging and inflammation to develop myelodysplastic syndrome exacerbated by p53 loss. Mechanisms of nucleophosmin … Web12 jun. 2024 · NPM1c binds to cleaved caspase-6 and 8, which are the active forms of these proteins, thereby exerting a gain of function by inhibiting their proteolytic activity . This … celtic 21 22 wiki
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Web13 nov. 2024 · These findings show that acute myeloid leukemia cells expressing the NPM1 mutant gene are highly dependent on continued export of protein NPM1c to proliferate … http://www.cell-stress.com/researcharticles/nucleolar-stress-hallmarks-sensing-mechanism-and-diseases/ WebOn April 13, 2024 Biomea Fusion, Inc. ("Biomea")(Nasdaq: BMEA), a clinical-stage biopharmaceutical company dedicated to discovering and developing novel covalent small molecules to treat and improve the lives of patients with genetically defined cancers and metabolic diseases, reported the upcoming presentation of two preclinical abstracts at … celtic 2022 champions