WebIn chordate animals, gap junction channels are encoded by a family of genes called “connexins” ( Goodenough, 1974 ), which can be categorized into three groups known as α, β, and γ according to their gene structure, overall gene homology, and specific sequence motifs ( Harris, 2001 ). WebPhosphorylation of connexins has various effects on GJC and plays major roles at several steps of the connexin lifecycle, including trafficking, assembly/disassembly, degradation, and gating ( Lampe and Lau, 2004 ).
Connexins in skeletal muscle development and disease
Web14. apr 2024. · Upgrading to ImageView software can extend the value and life of your X-ray imaging equipment. A second example is Carestream’s Chest Image Auto-Correct … Web10. dec 2015. · Life cycle of connexins in health and disease. Laird DW Biochem J, (Pt 3):527-543 2006 MED: 16492141 Turnover and phosphorylation dynamics of connexin43 gap junction protein in cultured cardiac myocytes. Laird DW , Puranam KL , Revel JP Biochem J, 67-72 1991 MED: 1846532 shovelnose sturgeon caviar
Mechanisms linking connexin mutations to human diseases
Web30. sep 2024. · Gap junctions (GJ) and connexins play integral roles in cellular physiology and have been found to be involved in multiple pathophysiological states from cancer to cardiovascular disease. Studies over the last 60 years have demonstrated the utility of altering GJ signaling pathways in experimental models, which has led to them being … Web01. feb 2016. · Connexins are highly regulated proteins due to an unusually short half-life of only a few hours [9], allowing the extent of gap junctional intercellular communication ... Life cycle of connexins in health and disease. Biochem. J., 394 (2006), pp. 527-543. View in Scopus Google Scholar [9] Web01. feb 2016. · While the 21 member multi-gene family of connexins are ubiquitously found in humans, only Cx39, Cx40, Cx43 and Cx45 have been documented in developing myoblasts and injured adult skeletal muscle while healthy adult skeletal muscle is … shovelnose sturgeon fish