2024 Cisplatin mitophagy

Cisplatin mitophagy

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August undefined, 2024

WebCisplatin is widely recommended in combination for the treatment of tumors, thus inevitably increasing the incidence of cisplatin-induced acute kidney injury. Mitophagy is a type of … WebNov 11, 2024 · Mitophagy reportedly can prevent diabetic nephropathy, cisplatin-induced AKI and other related nephropathy. In this study, we evaluated the correlation between mitophagy and the protective effect of the Nrf2 activator farrerol on cisplatin-induced CKD by using C57BL/6 wild-type and Nrf2 knockout mice.

Cisplatin resistance can be curtailed by blunting Bnip3-mediated ...

WebCisplatin is widely recommended in combination for the treatment of tumors, thus inevitably increasing the incidence of cisplatin-induced acute kidney injury. Mitophagy is a type of mitochondrial quality control mechanism that degrades damaged mitochondria and maintains cellular homeostasis. WebApr 22, 2024 · Specifically, levels of the mitophagy receptor BNIP3 are higher both in resistant cells and in ovarian cancer patient samples resistant to platinum-based treatments. Genetic BNIP3 silencing or pharmacological inhibition of autophagosome formation re-sensitizes these cells to CDDP. cannagather nj

Apurinic endonuclease 1 promotes the cisplatin resistance of lung ...

In vivo, we initially identified the occurrence of autophagy/mitophagy during cisplatin treatment in C57/BL6 mice. C57BL/6 mice (male, 8–10 weeks old) were intraperitoneally injected with 30 mg/kg cisplatin or saline as control. Blood samples were harvested to measure serum creatinine and blood urea … See more To assess the role of mitophagy on cisplatin-induced AKI in C57BL/6 mice, we investigated the effect of rapamycin, a pharmacological … See more Under unchallenged conditions, serum creatinine, and BUN were at low levels in both Parkin-KO mice and their WT littermates, indicating that renal function was normal in these … See more To determine the role of PINK1/Parkin pathway of mitophagy in cisplatin-induced nephrotoxicity, we tested Parkin- or PINK1-KO mouse models. We first verified Parkin deficiency in … See more WebThe cardiotoxic effect of chemotherapeutic agents as cisplatin has become a major issue recently. Interference with mitochondrial dynamics, biogenesis, redox status, and apoptosis are the most possible underlying mechanisms. ... Cisplatin has disturbed mitochondrial function and dynamics, dysregulate redox status and induced mitophagy and ... WebCisplatin exerts its therapeutic efficacy by interfering with DNA replication but also by interacting with other nucleophilic species within cells, including side chains of mitochondrial proteins and nucleotides. Mitochondria are key signaling hubs that fundamentally contribute to cancer development and progression. fix macbook pro keyboard issue

Involvement of mitophagy in cisplatin-induced cell death regulation

Autophagy regulates cisplatin-induced stemness and ... - PubMed

WebMar 28, 2024 · Cisplatin chemotherapy often causes acute kidney injury (AKI) in cancer patients. There is increasing evidence that mitochondrial dysfunction plays an … WebJul 5, 2024 · Mitophagy is a cytoprotective process in the adaptation to chemotherapy drug treatment. Therefore, targeting mitochondria is regarded as a promising anticancer … cannagar hemp wrapWebOct 7, 2024 · Chaetomugilin J Inhibits Mitophagy Induced by Cisplatin. Mitophagy is a type of autophagy that eliminates redundant or damaged mitochondria. 26 It plays an important role in mitochondrial function. The expression of pink1 and parkin, which are mitophagy-related proteins, were detected to reflect mitophagy. cannagar products

"WebMar 15, 2024 · It has been found that PNS is able to alleviate cisplatin-induced nephrotoxicity by inducing BNIP3-mediated mitophagy via hypoxia-inducible factor-1α (HIF-1α). PNS treatment restores renal function via attenuating the accumulation of injury mitochondria and cell apoptosis in TECs ( Liang et al., 2024 ; Li et al., 2024c ). " - Cisplatin mitophagy

Cisplatin mitophagy

Cisplatin resistance can be curtailed by blunting Bnip3 …

WebFeb 13, 2024 · Cisplatin is widely recommended in combination for the treatment of tumors, thus inevitably increasing the incidence of cisplatin-induced acute kidney injury. Mitophagy is a type of mitochondrial quality control mechanism that degrades damaged mitochondria and maintains cellular homeostasis. Ferropt … WebJan 13, 2024 · Abstract. Cisplatin is an efficacious anticancer agent, but its use is limited by ototoxicity and resultant irreversible sensorineural hearing loss. …

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WebBackground: To study the protective effect of berberine (BBR) on cisplatin-induced acute kidney injury (AKI) and its effect on mitophagy. Methods: (I) Male C57BL/6 mice aged 6-8 weeks were randomly divided into control group (saline), cisplatin group (cisplatin), and cisplatin + BBR (5, 10 mg/kg) groups. WebMar 7, 2024 · Recently, some authors believed that miR34a and mitophagy played a role in age-related and drug-induced hearing loss. Our study aimed to explore the involvement of miR-34a/DRP-1-mediated mitophagy in cisplatin-induced ototoxicity. Methods: In this study, C57BL/6 mice and HEI-OC1 cells were treated with cisplatin.

WebMar 12, 2024 · The results have indicated that co-administration of melatonin and sorafenib induced an early mitophagic response in Hep3B cells and the status of mitochondrial membrane depolarization as a marker... WebMay 20, 2024 · Cisplatin ototoxicity is associated with cochlear cell oxidative stress and mitochondrial damage. However, mitophagy is vital for maintaining mitochondrial quality and cellular metabolism. Accordingly, we investigated the role of mitophagy in regulating cisplatin-induced ototoxicity using the auditory cell line HEI-OC1.

WebOct 12, 2024 · Gastric cancer (GC) is one of the most common tumors worldwide, and cisplatin is a standard chemotherapeutic reagent for GC treatment. However, chemoresistance is an inherent challenge which limits its application and effectiveness in clinic. This study aims to investigate the mechanism of metformin-induced cisplatin … WebCisplatin is a widely used chemotherapeutic agent. Here we show that cisplatin induces apoptosis in renal collecting duct-derived cells (MDCK-C7 cells, resembling principal …

WebNov 11, 2024 · Mitophagy reportedly can prevent diabetic nephropathy, cisplatin-induced AKI and other related nephropathy. In this study, we evaluated the correlation between …

WebJan 16, 2024 · We examined the sensitivity of 20 human cancer cell lines to X-rays, carbon ions, or cisplatin in a clonogenic survival assay (Figs 1,2).Details of the parameters … cannage industrielWebOct 1, 2024 · The production of NAD + was elevated in the early stage of mild stimulation of cisplatin, while it was significantly consumed in the end. As one of the most important organelles in cell, mitochondria take charge of vital functions like energy production and ROS elimination. cannagather bostonWebNov 26, 2024 · Cisplatin is one of the commonly used anticancer drugs in clinic chemotherapy, but drug resistance is a major therapeutic obstacle for successful treatment. While ginkgolic C17:1 alone induced autophagy and apoptosis in the human hepatoblastoma cells HepG2, it was found to paradoxically inhibit cisplatin-induced … cannaghanallyWebDec 1, 2024 · The “oncoPredict” package showed that the high risk mitophagy group had a lower sensitive score than low risk mitophagy group in a series of drugs (Table 1). To be noted, compared to low risk mitophagy group, the high risk mitophagy was more sensitive to cisplatin and gemcitabine, which were often used in the treatment of LUAD. 3.5. cannagatherWebSep 18, 2024 · NCBI Bookshelf cannagea fort collinsWebA total of 407 drugs are known to interact with cisplatin : 77 major drug interactions (291 brand and generic names) 311 moderate drug interactions (1044 brand and generic … cannage stickersWebAug 7, 2024 · Mitophagy, a term first proposed by Lemasters (2005), refers to a process by which mitochondria are selectively degraded by autophagy ( Palikaras et al., 2024 ), which has emerged as an important mechanism of mitochondrial quality and quantity control ( Pickles et al., 2024 ). fix macbook pro screen 2011