C-terminal agrin fragment
WebJun 7, 2012 · C-terminal Agrin Fragment could be a potential marker for identifying sarcopenia in a subgroup of affected individuals in the future. The decline of muscle mass seems to be a CAF-associated process in males, whereas the situation in females may be more complex and multifactorial. CAF concentration is reduced by vitamin D … WebJul 5, 2016 · The C-Terminal Fragment of Agrin (CAF), a Novel Marker of Renal Function, Is Filtered by the Kidney and Reabsorbed by the Proximal Tubule Arezoo Daryadel, …
C-terminal agrin fragment
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WebJun 24, 2024 · C-terminal fragment of agrin (CAF), a proteoglycan of the glomerular and tubular basement membrane, have been recently associated with rapid renal function deterioration and proximal tubular dysfunction. It is unknown whether elevated CAF levels may serve as a novel AKI biomarker in patients presenting with AMI. Methods WebJan 1, 2013 · The C-terminal Agrin Fragment caused by degeneration of the neuromuscular junction can be measured in human serum. CAF appears to be a …
WebAgrin is a multifunctional component of the synaptic basal lamina. The C-terminal region of agrin has been most extensively studied, since this is the region that is sufficient to induce the aggregation of AChRs. The number of other molecules that interact with agrin at the neuromuscular junction is extensive. WebDec 19, 2024 · The proposed circulating C-terminal agrin fragment (CAF) estimation has been shown to be elevated in conditions associated with sarcopenia.[891011] Disruption …
WebAgrin is a multifunctional component of the synaptic basal lamina. The C-terminal region of agrin has been most extensively studied, since this is the region that is sufficient to induce the aggregation of AChRs. The number of other molecules that interact with agrin at the neuromuscular junction is extensive. WebAgrin C-terminal 22 kDa fragment: this released fragment is important for agrin signaling and to exert a maximal dendritic filopodia-inducing effect. All 'z' splice variants (z+) of this fragment also show an increase in the …
WebMay 16, 2024 · Recently, the relevance of circulating C-terminal agrin fragment (CAF) as an accessible screening method alternative for sarcopenia has gained credence. …
WebJan 28, 2024 · C‐terminal agrin fragment (CAF) (A) and neurofilament light chain (NfL) (B) serum concentration differences between a young (Young) reference population measured in our laboratory and the pooled old sarcopenic (O‐Sarc) participants of the present study at baseline. Differences were assessed via unpaired t‐test. NfL values did not pass the ... bankomat kb cercanyWebJan 1, 2013 · This large C-terminal agrin fragment is called AgC110 herein. A large N-terminal fragment of agrin (AgN200) which results by cleavage only at the β-site with a … posolstvo rossii v helsinkiposnet saltaWebJul 15, 2024 · Agrin is a protein released by motor neurons into the synaptic cleft and is required for the clustering of acetylcholine receptors. Proteolytic cleavage of agrin into its breakdown products called C-terminal agrin fragments (CAF) triggers the destabilization of the neuromuscular junction (NMJ) in multiple catabolic conditions. bankomat kb monetaWebFeb 20, 2024 · C-terminal agrin fragment (CAF) is a circulatory by-product of agrin cleavage by synaptic protease neurotrypsin , a process which can lead to neuromuscular junction breakdown . In healthy older adults (17, 18) and people with heart failure , CAF levels are elevated in those with low, compared to with normal, SMM. Thus, declining … bankomat kbWebOct 29, 2014 · C-terminal agrin fragment (CAF, size 22 kDa) is a promising new biomarker for kidney function. This study evaluated the usefulness of CAF as a serum biomarker for residual renal function (RRF) in patients undergoing automated peritoneal dialysis (APD). Patients and methods bankomat kb pacovWebOct 29, 2014 · C-terminal agrin fragment (CAF, size 22 kDa) is a promising new biomarker for kidney function. This study evaluated the usefulness of CAF as a serum biomarker for … posologie ovule myleugyne